INSIGHT INTO THE MECHANISM OF CYTOTOXICITY OF MEMBRANE-PERMEANT PSORALENIC KV1.3 CHANNEL INHIBITORS BY CHEMICAL DISSECTION OF A NOVEL MEMBER OF THE FAMILY

The potassium channel Kv1.3, involved in several important pathologies, is the target of a family of psoralen-based drugs whose mechanism of action is not fully understood.Here we provide evidence for a physical interaction of the mitochondria-located Kv1.3 (mtKv1.3) and Complex I of the respiratory chain and show that this proximity underlies the

With the development of high-frequency carriers and high-capacity communications, ultrahigh-speed spectrum analyzer based on all-optical methods has been demonstrated in many fields.Limited by current data processing algorithms, ultrahigh-speed spectrum analyzers based on time-lens, such as frequency-domain light intensity spectrum analyzer (f-LISA

Abstract Objectives This dataset presents demographic, psychological, auditory and neurophysiological information of 31 volunteers, who participated in Accent Mirror (Set of 3) an experiment measuring the auditory immersive experience in two audio formats: stereophonic downmix and three-dimensional audio.This dataset could help understand the objec

Cultural heritage plays an important role in the tourism sector nowadays.When the European Union realised this, it started founding programs, aiming at, one the one hand, preserving cultural heritage and, on the other hand, assigning functions to them to attract tourists.The programs are in Floor Sealer cooperation with the governments of the membe